A New Biofilm Assay
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As part of the development of the next generation of antimicrobials, techniques must be developed and set in place to determine efficacy of these ‘new’ antimicrobials against cells grown in biofilms.
A NEW BIOFILM ASSAY
As part of the
development of the next generation of antimicrobials, techniques must be
developed and set in place to determine efficacy of these ‘new’ antimicrobials
against cells grown in biofilms. Antimicrobial assays include those targeted at
identifying antimicrobials effective against biofilms. It is tempting to
speculate that, since screening of all combinatorial libraries of antibiotics
was based on efficacy against planktonic targets, potential new antibiotics
with efficacy against chronic disease may have been overlooked. The potential
of identifying ‘next-generation’ antibiotics in existing libraries by
appropriate biofilm screens is a distinct possibility. The ability to now
produce multiple reproducible biofilms of defined target size provides the potential
for high throughput screens for antibiotic efficacy against biofilms.
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