A New Biofilm Assay

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Chapter: Pharmaceutical Microbiology : Microbial Biofilms: Consequences For Health

As part of the development of the next generation of antimicrobials, techniques must be developed and set in place to determine efficacy of these ‘new’ antimicrobials against cells grown in biofilms.


A NEW BIOFILM ASSAY

 

As part of the development of the next generation of antimicrobials, techniques must be developed and set in place to determine efficacy of these ‘new’ antimicrobials against cells grown in biofilms. Antimicrobial assays include those targeted at identifying antimicrobials effective against biofilms. It is tempting to speculate that, since screening of all combinatorial libraries of antibiotics was based on efficacy against planktonic targets, potential new antibiotics with efficacy against chronic disease may have been overlooked. The potential of identifying ‘next-generation’ antibiotics in existing libraries by appropriate biofilm screens is a distinct possibility. The ability to now produce multiple reproducible biofilms of defined target size provides the potential for high throughput screens for antibiotic efficacy against biofilms.

 

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