Aldose reducatse inhibitors

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Chapter: Medicinal Chemistry : Oral Hypogylcaemic Drugs

Oral Hypogylcaemic Drugs : Aldose reducatse inhibitors - i. Sorbinil ii. Tolrestat


SYNTHESIS AND DRUG PROFILE

Aldose reducatse inhibitors

In diabetic complications, high concentrations of glucose is converted into sorbitol by aldose reductase  by the polyol pathway (Fig. 1.4). Sorbitol is converted into fructose and these products accumulate in the nerves, kidneys, and retina, etc. Galactone is converted to galacitol, which is not metabolized and causes osmotic swelling. Aldose reductase inhibitors interfere in the polyol pathway of sorbitol and fructose and thereby cause hypoglycaemic effects.


 

i. Sorbinil


Uses: It is used in the treatment of diabetic neuropathy.

 

ii. Tolrestat


Uses: It is useful in the prophylaxis of diabetic neuropathy and cataracts.

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