Alzheimer’s Disease

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Chapter: Medicinal Chemistry : Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder primarily manifesting as a loss of memory, senile dementia, intraneuronal neurofibrillary tangle formation.


Alzheimer’s Disease

INTRODUCTION

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder primarily manifesting as a loss of memory, senile dementia, intraneuronal neurofibrillary tangle formation, and cerebral parenchyma deposition of the ß-amyloid protein in the form of amyolid plaques and these constitutes the most stereotypic cognitive deficts and neuro-pathological hallmarks of AD. The earliest striking symptom is loss of shortterm memory (amnesia). Behavioural disturbances include agitation, aggression, and depressive mood; sleep disorder and anxiety. AD was the 7th leading cause of death in 2004 with 65,829 number of deaths. There are an estimated 24 million people with dementia worldwide.


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