Angiotensin II Antagonist

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Chapter: Medicinal Chemistry : Antihypertensive Drugs

Antihypertensive Drugs: Angiotensin II Antagonist - Synthesis and Drug Profile - i. Losartan ii. Irbesartan iii. Candesartan iv. Telmisartan v. Valsartan - Structure, Properties, uses, Synthesis | Synthesis and Drug Profile


SYNTHESIS AND DRUG PROFILE


Angiotensin II Antagonist


i. Losartan


Properties and uses: It exists as white crystalline powder that is soluble in water, alcohol, acetonitrile, or 2-butanone. It is used as an antihypertensive agent and also in the treatment of heart failure.


ii. Irbesartan


Properties and uses: It exists as white crystals that are soluble in ethanol or methylene chloride. It is an angiotensin II receptor antagonist.


iii. Candesartan


Properties and uses: It exists as colourless crystals and is used as an angiotensin II receptor antagonist.


iv. Telmisartan


Properties and uses: It exists as a white solid, insoluble in water or in aqueous solutions. It is used as an antihypertensive agent.


v. Valsartan


Properties and uses: It exists as white crystals and it is a nonpeptide angiotensin II receptor antagonist.


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