Anthranilic Acid Derivative (Fenamate)

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Chapter: Essential pharmacology : Nonsteroidal Anti-inflammatory Drugs And Antipyreticanalgesics

An analgesic, antipyretic and weaker anti-inflammatory drug, which inhibits COX as well as antagonises certain actions of PGs. Mephenamic acid exerts peripheral as well as central analgesic action.


ANTHRANILIC ACID DERIVATIVE (FENAMATE)

 

Mephenamic Acid

 

An analgesic, antipyretic and weaker anti-inflammatory drug, which inhibits COX as well as antagonises certain actions of PGs. Mephenamic acid exerts peripheral as well as central analgesic action.

 

Adverse Effects

 

Diarrhoea is the most important doserelated side effect. Epigastric distress is complained, but gut bleeding is not significant. Skin rashes, dizzines and other CNS manifestations have occurred. Haemolytic anaemia is a rare but serious complication.

 

Pharmacokinetics

 

Oral absorption is slow but almost complete. It is highly bound to plasma proteins—displacement interactions can occur; partly metabolized and excreted in urine as well as bile. Plasma t½ is 2–4 hours.

 

Uses

 

Mephenamic acid is indicated primarily as analgesic in muscle, joint and soft tissue pain where strong anti-inflammatory action is not needed. It is quite effective in dysmenorrhoea. It may be useful in some cases of rheumatoid and osteoarthritis but has no distinct advantage.

 

Dose: 250–500  mg  TDS;  MEDOL  250,  500  mg  cap;

 

MEFTAL 250, 500 mg tab, 100 mg/5 ml susp.

 

PONSTAN 125, 250, 500 mg tab, 50 mg/ml syrp.

 

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