Antileprotic Drugs

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Chapter: Medicinal Chemistry : Antileprotic Drugs

Leprosy is a chronic disease caused due to acid-fast bacillus called Mycobacterium leprae and produces nodules on the skin and causes loss of sensation.


Antileprotic Drugs

INTRODUCTION

Leprosy is a chronic disease caused due to acid-fast bacillus called Mycobacterium leprae and produces nodules on the skin and causes loss of sensation. Once the organism enters into the body, it multiplies and produces antigen–antibody reaction and causes cell-mediated immunity, and produces allergic reaction by the metabolite of the microorganism and finally produces lepra reaction.

 

Categories of Leprosy

1.           Tuberculoid leprosy

2.           Lepromatous leprosy

3.           Intermediate leprosy

4.           Borderline leprosy

 

Lepromatous leprosy: Large number of organisms that are present in the affected area and induce lepra reaction.

Tuberculoid leprosy: Is characterized by skin molecules with clear centre and well-defined margin.

Intermediate leprosy: Is localized hypo-pigmentation with some sensory loss.

Borderline leprosy: It is an intermediate stage between tuberculoid leprosy and lepromatous leprosy.

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