Antimalarials

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Chapter: Medicinal Chemistry : Antimalarials

Antimalarial agents are drugs used for the treatment or prophylaxis of malaria. Malaria is caused by four species of Plasmodium, such as Plasmodium falciparum, P. malariae, P. ovale, and P. vivax.


Antimalarials

INTRODUCTION

Antimalarial agents are drugs used for the treatment or prophylaxis of malaria. Malaria is caused by four species of Plasmodium, such as Plasmodium falciparum, P. malariae, P. ovale, and P. vivax. Three of which produces the mild forms of malaria by destroying red blood cells in peripheral capillaries and thus, causing anaemia. The bouts of fever correspond to the reproductive cycle of the parasite. However, the most dangerous is the P. falciparum. In this case, the infected red blood cells become sticky and form lumps in the capillaries of the deep organs of the body and cause microcirculatory arrest. This disease still affects about 200 millions people and causes at least 2 million deaths per year.

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