Classification of Antidepressants

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Chapter: Medicinal Chemistry : Antidepressants

I. Monoamine oxidase inhibitors (MAOIs) II. Tricyclic antidepressants (TCAs) III. Second-generation antidepressants IV. Selective serotonin reuptake inhibitors (SSRIs) V. Selective NE reuptake inhibitors VI . Benzodiazepines VII. Electro convulsive therapy VIII. Miscellaneous


CLASSIFICATION

These drugs vary significantly in their chemical and pharmacological properties. One convenient way is to combine both aspects and classify accordingly.


I. Monoamine oxidase inhibitors (MAOIs)



Harmine, Harmaline

α-methyl tryptamine, α-ethyl tryptamine


II. Tricyclic antidepressants (TCAs)


1. Imino dibenzyl derivatives



2. Dibenzo cycloheptane derivatives


2. Dibenzoxepine derivatives



4. Dibenzoxazepine derivatives



III. Second-generation antidepressants

  1. Bicyclic: Viloxamine, Zimeldine

  2. Tricyclic: Dibenzepine, Amoxapine, Imprindole

  3. Tetracyclic: Mamprotiline, Mianserin


IV. Selective serotonin reuptake inhibitors (SSRIs)



V. Selective NE reuptake inhibitors

a. Venlafaxine


b. Nisoxetin

c. Roboxetine


VI . Benzodiazepines

a. Alprazolam


VII. Electro convulsive therapy


VIII. Miscellaneous

  1. ß-Adreno receptor agonists salbutamol, clenbutral

  2. Thyrotropine releasing hormone (TSH)

  3. Others: trazadone, nomifenzine, bupropion, fluvoxamine


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