Classification of Antihypertensive Drugs

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Chapter: Medicinal Chemistry : Antihypertensive Drugs

I. Diuretics II. Drugs acting on sympathetic system III. Calcium channel blockers IV. Drugs acting on renin-angiotensin system V. Vasodilators VI. Miscellaneous


CLASSIFICATION


I. Diuretics

a. Thiazides

i. Chlorthiazide


ii. Hydrochlorthiazide


iii. Cyclopenthiazide


iv. Bendroflumethiazide



b. Loop diuretics

i. Frusemide or furosemide


ii. Ethacrynic acid


iii. Bumetanide



c. Potassium-sparing diuretics

i. Triamterene


ii. Spiranolactone (Aldosterone antagonists)



II. Drugs acting on sympathetic system

a. Centrally acting drugs

i. Clonidine


ii. α-Methyl dopa


iii. Guanabenz



b. Catacholamine depletors 

Reserpine


c. Adrenergic blockers


i. β-adrenergic blockers

1. Propronolol


2. Atenolol


3. Metoprolol


4. Oxprenolol


5. Acebutalol


6. Timolol


7. Nadolol


8. Pindolol



ii. α-Aderenergic blockers

1. Phentolamine


2. Phenoxy benzamine hydrochloride


3. Tolazoline


4. Prazosin


5. Terazosin


6. Doxazosin



iii. Mixed α and β blockers (nonselective)

1. Labetalol


2. Carvedilol



iv. Imidazoline receptor agonist

1. Moxonidine


2. Rilmenidine


d. Aderenergic neuron blockers

i. Guanethidine

ii. Guanoxan

iii. Debrisoquine

iv. Bethanidine



e. Ganglion blockers

i. Quaternary ammonium compounds

1. Hexamethonium bromide


2. Pentolinium tartarate


ii. Secondary amines

1. Mecamylamine HCl


iii. Tertirary amines

1. Pempidine


2. Trimethophan


III. Calcium channel blockers

i. Verapamil


ii. Nifedipine




IV. Drugs acting on renin-angiotensin system

a. Drugs that block renin release—Propranolol.

b. Drugs that inhibit angiotensin II—Saralasin.

c. Drugs that inhibit angiotensin II receptors.


d. Drugs that inhibit aldosterone—Spironolactone

e. ACE inhibitors

i. Sulphahydryl containing ACE inhibitors 

Captopril


ii. Dicarboxylate containing ACE inhibitors




V. Vasodilators



VI. Miscellaneous

MAO inhibitors—Pargyline, Metyrosine, Pinacidil


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