Classification of Antiparkinsonism Agents

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Chapter: Medicinal Chemistry : Antiparkinsonism Agents

The drugs used in the treatment of parkinsonism can be classified as follows: I. Drugs affecting brain dopamine II. Anticholinergic agents III. Miscellaneous drugs


CLASSIFICATION

The drugs used in the treatment of parkinsonism can be classified as follows:


1. Drugs affecting brain dopamine


i. Drugs that increase brain levels of dopamine

a. Levodopa



ii. Drugs that decrease dopamine metabolism



iii. Dopamine releasers



iv. Dopamine receptor stimulation: Dopaminergic agonists


v. Dopamine conservation, MAO-B Inhibitor



II. Anticholinergic agents


i. Piperidine analogues



ii. Pyrrolidine analogues


a. Procyclidine HCl



iii. Phenothiazine anaologues

a. Ethopropazine HCl


Antihistamines with central anticholinergic activity

b. Diphenhydramine



III. Miscellaneous drugs

  • Antidepressants: Amitriptyline, trazadone

  • α-tocopherol (vitamine E)

  • Glutamate release inhibitor: Lamotrigine

  • Glutamate receptor antagonist: Remacemide

  • Glial-derived neurotrophic factor: GDNF

  • Benztropine

  • Orphenadrine citrate

  • Chlorphenoxamine HCl


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