Classification of Cholinergic Drugs

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Chapter: Medicinal Chemistry : Cholinergic Drugs

I. Directly acting cholinergic drugs A. Choline esters B. Cholinomimetic alkaloids II. Indirectly acting cholinergic drugs A. A Reversible cholinesterase inhibitors B. Irreversible cholinesterase inhibitors


CLASSIFICATION

These agents mimic the actions of acetylcholine at parasympathetic system and based on their mechanism of action, they are classified as follows:


I. Directly acting cholinergic drugs

A. Choline esters



B. Cholinomimetic alkaloids



II. Indirectly acting cholinergic drugs 

A. A Reversible cholinesterase inhibitors

i. Physostigmine (Eserine)


ii. Neostigmine bromide (Pristigmine)


iii. Pyridostigmine bromide (Mestinon)


iv. Edrophonium chloride


v. Ambenonium chloride (mytelase)


vi. Demecarium (Humorsol)


vii. Distigmine (Ubretid)


B. Irreversible cholinesterase inhibitors

a. Pralidoxime chloride


b. Echothiopate iodide


c. Malathion


d. Isofluorphate


e. Parathion



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