Dipyridamole

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Chapter: Medicinal Chemistry : Antianginals

Antianginals : Dipyridamole - Synthesis and Drug Profile


SYNTHESIS AND DRUG PROFILE


Miscellaneous

i. Dipyridamole


Synthesis


Properties and uses: It is a bright yellow crystalline powder, which dissolves in dilute solutions of mineral acids, but insoluble in water, soluble in acetone and ethanol. The drug inhibits adenosine deaminase in erythrocytes and interacts with the uptake of vasodilator adenosine by erythrocytes. These actions potentiate the effect of prostacyclin, which acts as an inhibitor to platelet aggregation. It is a long-acting vasodilator. Its vasodilating effect is selective for the coronary system. It is also used to treat angina pectoris.

Assay: Dissolve the sample in methanol and titrate with 0.1 M perchloric acid. Determine the end point potentiometrically.

Storage: It should be stored in well-closed airtight containers and protected from light.

Dosage forms: Dipyridamole tablets B.P.


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