Drugs for Trichomoniasis

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Chapter: Essential pharmacology : Antiamoebic And Other Antiprotozoal Drugs

Trichomonas vaginalis is another flagellate protozoon which causes vulvovaginitis. A large number and variety of drugs are effective by vaginal application, but may not entirely clear the infection; recurrences are frequent; repeat courses are required.


DRUGS FOR TRICHOMONIASIS

 

Trichomonas vaginalis is another flagellate protozoon which causes vulvovaginitis. A large number and variety of drugs are effective by vaginal application, but may not entirely clear the infection; recurrences are frequent; repeat courses are required.

 

1. Drugs Used Orally

 

Metronidazole 400 mg TDS for 7 days or 2 g single dose, or Tinidazole 600 mg daily for 7 days or 2 g single dose or Secnidazole 2 g single dose, are the drugs of choice. They produce >90% cure. However, vaginitis due to nitroimidazole resistant T. vaginalis is being reported from some parts of the world. Additional intravaginal treatment is required only in refractory cases. A hard core of recurrent cases may remain. A repeat course can be given after 6 weeks, and additional treatment for nonspecific vaginosis often helps. In some cases recurrences are due to reinfection from the male partner who harbours the parasite in the seminal vesicles but remains asymptomatic. In such cases, both partners should be treated concurrently to prevent cross infection of each other.

 

Nimorazole: It is another orally effective nitroimidazole; 2 g single dose taken with meals has produced satisfactory response in trichomonas vaginitis.

 

FLOSOGYN 250 mg tab.

 

2. Drugs Used Intravaginally

 

Diiodohydroxyquin 200 mg inserted intravaginally at bed time for 1–2 weeks; FLORAQUIN 100 mg vaginal pessaries.

 

Quiniodochlor 200 mg inserted in the vagina every night for 1–3 weeks; GYNOSAN 200 mg vaginal tab.

 

Clotrimazole 100 mg inserted highup in vagina every night for 6–12 days; SURFAZ 100 mg vaginal tab.

 

Hamycin 4–8 lac U intravaginally daily for 15 days; HAMYCIN VAGINAL 4 lac U ovules.

 

Natamycin 25 mg nightly intravaginal application for 10 days; NATAMYCIN 25 mg vaginal tab.

 

Povidoneiodine 400 mg inserted in the vagina daily at night for 2 weeks; BETADINE VAGINAL 200 mg pessaries.

 

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