Echinocandins-Caspofungin, Anidulafungin and Micafungin

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Chapter: Pharmaceutical Microbiology : Mechanisms of action of antibiotics and synthetic anti-infective agents

These members of the echinocandin group of antifungal agents have been developed for treatment of serious fungal infections. They interfere with the synthesis of the β-1,3-d-glucan polymer in the fungal cell wall.


ECHINOCANDINS—CASPOFUNGIN, ANIDULAFUNGIN AND MICAFUNGIN

 

These members of the echinocandin group of antifungal agents have been developed for treatment of serious fungal infections. They interfere with the synthesis of the β-1,3-d-glucan polymer in the fungal cell wall. Without the glucan polymer, the integrity of the fungal cell wall is compromised, yeast cells lose their rigidity and become like protoplasts; the effect is especially pronounced in Candida and Aspergillus species.

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