Factors affecting protein-drug binding can be broadly categorized as
FACTORS AFFECTING PROTEIN-DRUG BINDING
Factors affecting protein-drug binding can be
broadly categorized as—
1. Drug related factors
a. Physicochemical
characteristics of the drug
b. Concentration of drug in the
body
c. Affinity of a drug for a
particular binding component
2. Protein/tissue related factors
a. Physicochemical characteristics of the protein
or binding agent
b. Concentration of protein or
binding component
c. Number of binding sites on the
binding agent
3. Drug interactions
a. Competition between drugs for
the binding site (displacement interactions)
b. Competition between the drug
and normal body constituents
c. Allosteric changes in protein
molecule
4. Patient related factors
a. Age
b. Intersubject variations
c. Disease states
Related Topics
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