Fertilization

| Home | | Anatomy and Physiology | | Anatomy and Physiology Health Education (APHE) |

Chapter: Anatomy and Physiology for Health Professionals: Pregnancy and Development

1. List the steps involved in fertilization of the egg by the sperm. 2. What is the first cell of a future offspring called? 3. What would happen if more than one sperm cell head were to enter the oocyte?

Fertilization

Fertilization

Fertilization is the union of a sperm cell with an egg cell. Also called conception, it usually occurs in a uterine tube. Once the developing offspring is implanted into the lining of the uterus, pregnancy begins. It consists of three trimesters, each about three months long.

Once ovulation occurs, the egg cell usually enters a uterine tube. During sexual intercourse the male deposits semen into the vagina, near the cervix. The sperm cells in the semen must “swim” upward through the uterus and uterine tube. The female reproductive tract secretes a thin fluid that promotes sperm transport and survival. This secretion increases the chance that sperm will reach an egg cell at the time when a woman is most fertile. Within one hour after intercourse, sperm cells reach the upper uterinetube, where the secondary oocyte is located. Only one sperm actually fertilizes this egg cell.

Fertilization actually occurs once a sperm cell binds with the zona pellucida surrounding the oocyte cell membrane. The sperm cell’s acrosome releases enzymes such as hyaluronidase and acrosin, which aid penetration of the sperm head (FIGURE 26-1). At least several hundred sperm cells must be present to pro-duce enough enzymes to allow one of them to pene-trate. This is why men with very low sperm counts are termed subfertile.


When the head of a sperm enters the oocyte, the remainder stays outside, triggering vesicles beneath the oocyte membrane to strengthen the zona pellu-cida. This keeps additional sperm heads from entering. Entry of more than one would cause the zygote to be abnormal because of an overload of genetic material.

Once a sperm cell head enters the oocyte’s cyto-plasm and activates it, the sperm cell divides to form a large cell with a nucleus containing the female’s genetic information (FIGURE 26-2). It also holds a tiny second polar body, which is expelled. Meiosis is now complete, and the approaching nuclei from the two sex cells are called pronuclei. They later meet and merge, with their nuclear membranes disintegrating and their chromosomes mingling. Fertilization is now com-plete. Polyspermy or fertilization by more than one sperm is prevented by a cortical reaction that releases enzymes that inactivate sperm receptors while hardening the zona pellucida.


The male and female each provide 23 chromo-somes. A human body’s somatic cells require 46 ­chromosomes—hence the contributed chromosomes from each partner combine. The cell this produces is called the zygote—the first cell of the future offspring. Once the oocyte has been activated and meiosis has finished, the nuclear material that is still inside the ovum reorganizes­ into the female pronucleus. Mean-while, the nucleus of the spermatozoon swells to form the male pronucleus, as the remainder of the sperm cell breaks down. The two pronuclei join during amphi-mixis to form the zygote.


1. List the steps involved in fertilization of the egg by the sperm.

2. What is the first cell of a future offspring called?

3. What would happen if more than one sperm cell head were to enter the oocyte?

Contact Us, Privacy Policy, Terms and Compliant, DMCA Policy and Compliant

TH 2019 - 2024 pharmacy180.com; Developed by Therithal info.