Fusion Inhibitor

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Chapter: Essential pharmacology : Antiviral Drugs

Enfuvirtide This recently introduced HIV-derived synthetic peptide acts by binding to HIV1 envelope glycoprotein (gp41) and preventing fusion of viral and cellular membranes. Entry of the virus into the cell is thus blocked. It is not active against HIV2.


FUSION INHIBITOR

 

Enfuvirtide This recently introduced HIV-derived synthetic peptide acts by binding to HIV1 envelope glycoprotein (gp41) and preventing fusion of viral and cellular membranes. Entry of the virus into the cell is thus blocked. It is not active against HIV2. No cross resistance with other classes of ARV drugs occurs. Administered s.c., it is used as add on drug to an optimized regimen in patients who have failed many earlier regimens.

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