The information necessary to produce proteins in cells is encoded in the genetic material—the chromosomal strands, which are made of deoxyribo-nucleic acid (DNA).
Gene and gene
expression
The
information necessary to produce proteins in cells is encoded in the genetic
material—the chromosomal strands, which are made of deoxyribo-nucleic acid
(DNA). A gene is a sequence of the
chromosome that codes for a specific protein. Thus, genes are made of DNA and
contain information to produce specific proteins.
Transcription is a nuclear process
whereby information from DNA is transferred
to messenger ribonucleic acid (mRNA). In this process, the two complementary
strands of the DNA partly uncoil. The sense
strand sepa-rates from the antisense
strand. The antisense strand of DNA
is used as a template by the transcribing enzymes to assemble
complementarity-defined mRNA. Then, mRNA migrates into the cytoplasm, where
ribosomes transfer the encoded information in mRNA’s base sequence in a
comple-mentarity-defined manner to assemble proteins. This process is called translation. The long strings of amino
acids (called polypeptide chains) thus generated
can fold by themselves or assemble with other polypeptide chains to form a
specific protein. The covalently linked amino acids constitute the primary
structure of proteins. These folding and assembly processes hap-pen through
multiple noncovalent (such as hydrophobic, hydrogen bond, and ionic)
interactions, leading to the secondary, tertiary, and quaternary structure of
proteins. Some proteins additionally undergo posttranslational modifications,
such as the attachment of a glycan (carbohydrate) moiety to the protein by a
cytoplasmic enzyme. The assembled, functional proteins then migrate to their
site of action—which can be membrane, cytoplasmic, intraorgnelle (such as
intranuclear or intramitochondrial), or extracellular (secreted proteins, such
as hormones).
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