Host response to infection

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Chapter: Pharmaceutical Microbiology : Protozoa

Mechanisms to control parasitic protozoa are similar to those utilized for other infectious agents; they can be divided into non-specific mechanism(s) and specific mechanism(s) involving the immune system.


HOST RESPONSE TO INFECTION

 

Mechanisms to control parasitic protozoa are similar to those utilized for other infectious agents; they can be divided into non-specific mechanism(s) and specific mechanism(s) involving the immune system. The best studied nonspecific mechanisms include those that affect the entry of parasites into the red blood cell. The sickle cell haemoglobin trait and lack of the Duffy factor on the erythrocyte surface make the red cell more resistant to invasion by Plasmodium . These traits are commonly found in populations from malaria-endemic regions. A second example of a nonspecific factor is the presence of trypanolytic factors in the serum of humans which confer resistance to T. brucei, although nonspecific factors can play a key role in resistance, usually they work in conjunction with the host’s immune system.

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