Mast cells express high-affinity receptors (Fce) that bind the Fc domain of IgE antibodies. In the absence of antigen these receptors are occupied by the IgE monomer...
IMMEDIATE HYPERSENSITIVITY
Mast cells express high-affinity receptors
(Fce) that bind the Fc domain of IgE antibodies. In the absence of antigen
these receptors are occupied by the IgE monomer (antigen valency of 2) secreted
previously from plasma cells. In this circumstance the IgE molecules are
serving a cognitive function which, on appropriate antigen binding, results in
aggregation of the membrane-bound IgE and causes immediate mast cell
degranulation and release of inflammatory mediators. Mast cells possess in
their membranes IgE monomers able to recognize different antigenic epitopes.
This contrasts with each single B-lymphocyte, which possesses IgM antibody on
its surface membrane that performs a cognitive function but is capable of
recognizing only a single epitope specificity.
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