In vitro anticoagulants

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Chapter: Medicinal Chemistry : Coagulants

Coagulants: In vitro anticoagulants - i. Sodium citrate ii. Sodium oxalate - Synthesis and Drug Profile


SYNTHESIS AND DRUG PROFILE

In vitro anticoagulants

i. Sodium citrate


Synthesis


Properties and uses: Sodium citrate exists as white crystalline powder or granular crystals, soluble in water, but insoluble in alcohol and used as systemic alkalinizing substance.

Assay: Dissolve the sample in anhydrous acetic acid. Heat it, allow to cool and titrate against 0.1 M perchloric acid using naphtholbenzein as indicator until a green colour is obtained.

Dosage forms: Sodium citrate eye drops B.P., Sodium citrate irrigation solution B.P.

 

ii. Sodium oxalate


Synthesis


 

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