LDL Oxidation Inhibitors

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Chapter: Medicinal Chemistry : Antihyperlipidaemic Agents

Antihyperlipidaemic Agents : LDL Oxidation Inhibitors : Probucol (Lorelco) - Synthesis and Drug Profile - Structure, Properties, uses, Synthesis, Dose


SYNTHESIS AND DRUG PROFILE

LDL Oxidation Inhibitors 

Probucol (Lorelco)


4, 4’ [Methyl ethylidene] bis (thio) bis [2, 6-bis (1, 1-dimethylethyl)] Phenol

Properties and uses: It is a chemical agent that was developed for the plastic and rubber industry in 1960s. Probucol is a more potent cholesterol-lowering agent of a series of alkylidene dithio bisphenols. It is used as an antihyperlipoproteinaemic agent.

Dose: Adults only: 250–500 mg twice daily taken with morning and evening meals.

Synthesis



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