Leukotriene Receptors

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Chapter: Essential pharmacology : Prostaglandins, Leukotrienes (Eicosanoids) and Platelet Activating Factor

Separate receptors for LTB4 (BLT) and for the cysteinyl LTs (LTC4, LTD4) have been defined. Two subtypes, cys LT1 and cysLT2 of the cysteinyl LT receptor have been cloned. All LT receptors function through the IP3/DAG transducer mechanism.


LEUKOTRIENE RECEPTORS

 

Separate receptors for LTB4 (BLT) and for the cysteinyl LTs (LTC4, LTD4) have been defined. Two subtypes, cys LT1 and cysLT2 of the cysteinyl LT receptor have been cloned. All LT receptors function through the IP3/DAG transducer mechanism. The cysLT1 receptor antagonists, viz. Montelukast, Zafirlukast, etc are now valuable drugs for bronchial asthma (see Ch. No. 16).

 

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