Mechanisms of Resistance

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Chapter: Pharmaceutical Microbiology : Bacterial Resistance To Antibiotics

Resistance to antimicrobial agents typically occurs by one or more of the following mechanisms:


MECHANISMS OF RESISTANCE

 

Resistance to antimicrobial agents typically occurs by one or more of the following mechanisms:

• Inactivation of the drug

• Alteration of the target

• Reduced cellular uptake

• Increased efflux

In this chapter, resistance will be examined by agent, but attention will be drawn to mechanisms which can permit resistance to multiple, chemically different agents. 

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