Antiarrhythmic Drugs : Mild-to-moderate sodium channel blockers : i. Lidocaine ii. Phenytoin (Dilantin, Eptoin) iii. Mexiletine HCl iv. Tocainide HCl (Tonocard) - Synthesis and Drug Profile - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose
SYNTHESIS AND DRUG PROFILE
Mild-to-moderate sodium channel blockers
Synthesis and drug profile are discussed under sec III, ‘Local Anaesthetics’.
Synthesis
Synthesis and drug profile are discussed under sec III, Chapter ‘Anticonvulsants’.
Dose: Orally 15 mg/kg first day; 7.5 mg/kg on the second day, followed by 300 to 400 mg per day.
Synthesis
Properties and uses: It exists as white crystals, which is soluble in water and alcohol. It resembles lidocaine as it possesses a xylyl moiety, but is otherwise different chemically. Mexiletine is most useful in suppressing symptomatic ventricular arrhythmias.
Properties and uses: It exists as a white crystalline powder with bitter taste and soluble in water or in alcohol. Tocainide is another lidocaine congener and is similar to mexiletine in its electro-physiologic properties and antiarrhythmic action.
Dose: The usual dose is orally 400–1200 mg in two or three divided doses.
Synthesis
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