Miscellaneous

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Chapter: Medicinal Chemistry : Analgesics, Antipyretics, and NSAIDs

i. Nabumetone (Nabuflam, Niltis) ii. Nimesulide iii. Analgin - Synthesis and Drug Profile


Miscellaneous

 

i. Nabumetone (Nabuflam, Niltis)


Properties and uses: Nabumetone is a white crystalline powder, practically insoluble in water, freely soluble in acetone, and slightly soluble in methanol. It is a nonacidic compound and because of this nature, it produces minimum gastrointestinal side effect. It is indicated in the treatment of acute and chronic treatment of osteoarthritis and rheumatoid arthritis.

Synthesis


Dose: For pain and inflammation associated with osteoarthritis and rheumatoid arthritis adult dose is 1 g as a single dose in the evening followed by 0.5–1 g in the morning.

Dosage forms: Nabumetone oral suspension B.P., Nabumetone tablets B.P.

Assay: It is assayed by adopting liquid chromatography technique.

 

ii. Nimesulide


Synthesis


Properties and uses: Nimesulide is a yellowish crystalline powder, practically insoluble in water, soluble in acetone, and slightly soluble in anhydrous ethanol. It contains a sulphonamide moiety as an acidic group rather than a carbonic acid. It shows moderate incidence of gastric side effects because it exhibits significant selectivity towards COX-2, used as analgesic and anti-inflammatory agent.

 

iii. Analgin


Synthesis


Uses: Used as an analgesic and anti-inflammatory agent.

 

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