Miscellaneous/Adjuvant Haematinics

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Chapter: Essential pharmacology : Drugs Affecting Blood And Blood Formation

Haeme synthesis is interfered in copper deficiency. However, copper is a trace metal for man and clinical deficiency is very rare.


MISCELLANEOUS/ADJUVANT HAEMATINICS

 

Copper

 

Haeme synthesis is interfered in copper deficiency. However, copper is a trace metal for man and clinical deficiency is very rare. Its routine use is, therefore, not justified. However, when copper deficiency is demonstrated, 0.5–5 mg of copper sulphate/day may be given therapeutically; prophylactic dose is 0.1 mg/day. It is present in some haematinic combinations.

 

Cobalt

 

It stimulates erythropoiesis transiently, probably by inducing tissue hypoxia increased erythropoietin production. Cobalt deficiency is not known in man. Moreover, it can cause hypothyroidism, angina and CHF. It should not be prescribed.

 

Pyridoxine

 

Pyridoxine responsive anaemia is a rare entity. It is due to inherent abnormality in haeme synthesis. Sideroblastic anaemia associated with isoniazid and pyrazinamide (which interfere with pyridoxine metabolism and action) therapy needs to be treated with pyridoxine. Some other sideroblastic anaemias show partial improvement with large doses of pyridoxine. However, routine use of pyridoxine in anaemia is wasteful.

 

Riboflavin

 

Hypoplastic anaemia occurs in riboflavin deficiency which is generally a part of multiple deficiencies in proteincalorie malnutrition. In the absence of specific deficiency, use of riboflavin in anaemia is of no value.

 

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