Mucosal Immunity

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Chapter: Pharmaceutical Microbiology : Immunology

Mucosal immunity involves the interaction of antibody with antigen at mucosal surfaces such as those of the gastrointestinal tract, lung or urogenital tract.


MUCOSAL IMMUNITY


Mucosal immunity involves the interaction of antibody with antigen at mucosal surfaces such as those of the gastrointestinal tract, lung or urogenital tract. The major antibody of the mucosal lining fluid is IgA, which exists as a dimer of two monomer units (antigen valency of 4). IgA is actively secreted across mucosal epithelium into the lining fluid; it will neutralize antigen and may also serve as an opsonin. IgA is also present in secretions such as tears, saliva, etc. but it has a limited role in systemic immunity.

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