Other Hyperglycaemics

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Chapter: Essential pharmacology : Insulin, Oral Hypoglycaemic Drugs and Glucagon

Diazoxide : It inhibits insulin release from β cells and causes hyperglycaemia lasting 4–8 hours. Its action on ATP sensitive K+ channels is opposite to that of sulfonylureas.


OTHER HYPERGLYCAEMICS

 

Diazoxide

It inhibits insulin release from β cells and causes hyperglycaemia lasting 4–8 hours. Its action on ATP sensitive K+ channels is opposite to that of sulfonylureas. Other actions which may contribute to hyperglycaemia are decreased peripheral utilization of glucose and release of catecholamines. It has been used to prevent hypoglycaemia in insulinomas.

 

Thiazide diuretics and phenytoin

These are also mild hyperglycaemics.

 

Somatostatin

It causes hyperglycaemia primarily by inhibiting insulin release.

 

Streptozocin

It is obtained from Streptomyces achromogenes. Causes selective damage to insulin secreting β cells. It has been used to produce experimental diabetes in animals and to treat insulin secreting tumours of pancreas.


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