Penicillinase Susceptible Penicillins

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Chapter: Medicinal Chemistry : Antibiotics

Penicillinase Susceptible Penicillins : Penicillin-V


Penicillin - Synthesis and Drug Profile

Penicillinase Susceptible Penicillins

i. Penicillin-V


Synthesis


Properties and uses: Penicillin V is a white, odourless, crystalline powder with slightly bitter taste and soluble in water. It is more resistant to inactivation by gastric juice than penicillin G and better absorbed from the gastro intestinal (GI) tract. Equivalent oral doses provide two or five times greater plasma concentration than penicillin G. Penicillin V is given to treat ‘trench mouth’. It is useful in the treatment of streptococcal pharyngitis, pneumonia, arthritis, meningitis, and endocarditis caused by S. pyrogenes.

Dose: Dose of penicillin V by oral route is 125–500 mg six times daily for 10 days. For prophylaxis of rheumatic fever, the dose is 125–250 mg twice daily.

Assay: It is assayed by adopting liquid chromatography technique.

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