Phenoxyacetic acid derivatives - Nonmercurial diuretics

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Chapter: Medicinal Chemistry : Diuretics

Nonmercurial diuretics : Phenoxyacetic acid derivatives : Ethacrynic Acid - Synthesis and Drug Profile


SYNTHESIS AND DRUG PROFILE


Nonmercurial diuretics


Phenoxyacetic acid derivatives


i. Ethacrynic Acid


Synthesis


Properties and uses: It exists as a white crystalline powder that is odourless, soluble in alcohol, ether, or chloroform and in water, an aryloxyacetic acid derivative that is a potent, short-acting diuretic. It is used in the treatment of oedema caused by congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome.


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