Preparations of Thyroid Hormone

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Chapter: Essential pharmacology : Thyroid Hormones And Thyroid Inhibitors

l-thyroxine sod.: ELTROXIN, ROXIN 100 μg tab. THYRONORM, THYROX 25 μg, 50 μg, 100 μg tabs. Triiodothyronine (Liothyronine) 5, 25 μg tab—25 μg is equivalent to 100 μg of l-thyroxine: not freely available in India. It is occasionally used i.v. along with l-thyroxine in myxoedema coma.


PREPARATIONS

 

l-thyroxine sod.: ELTROXIN, ROXIN 100 μg tab. THYRONORM, THYROX 25 μg, 50 μg, 100 μg tabs. Triiodothyronine (Liothyronine) 5, 25 μg tab—25 μg is equivalent to 100 μg of l-thyroxine: not freely available in India. It is occasionally used i.v. along with l-thyroxine in myxoedema coma.

 

Oral bioavailability of l-thyroxine is ~ 75%, but severe hypothyroidism can reduce oral absorption. It should be administered in empty stomach to avoid interference by food. Sucralfate, iron and calcium also reduce l-thyroxine absorption. Enzyme inducers like rifampin, phenytoin and carbamazepine accelerate metabolism of T4; dose of l-thyroxine may need enhancement. Clinically, l-thyroxine is preferred for all indications over liothyronine because of more sustained and uniform action as well as lower risk of cardiac arrhythmias.

 

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