Prostaglandins - Uterine Stimulants

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Chapter: Essential pharmacology : Oxytocin And Other Drugs Acting On Uterus

PGE2, PGF2α and 15methyl PGF2α are potent uterine stimulants, especially in the later part of pregnancy and cause ripening of cervix.


PROSTAGLANDINS

 

PGE2, PGF2α and 15methyl PGF2α are potent uterine stimulants, especially in the later part of pregnancy and cause ripening of cervix. Their actions and use in obstetrics is described in Ch. No. 13. Since misoprostol (a PG analogue used for peptic ulcer) produces less side effects, it is being used for obstetric indications also.

 

Ethacridine

 

Available as 50 mg/50 ml solution (EMCREDIL, VECREDIL) for extraamniotic infusion: 150 ml (containing 150 mg) is injected slowly for medical termination of pregnancy in the 2nd trimester. This is an alternative method used occasionally.

 

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