Regulation of Secretion of Thyroid Hormone

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Chapter: Essential pharmacology : Thyroid Hormones And Thyroid Inhibitors

The secretion of hormones from the thyroid is controlled by anterior pituitary by the elaboration of thyrotropin.


REGULATION OF SECRETION

 

The secretion of hormones from the thyroid is controlled by anterior pituitary by the elaboration of thyrotropin. The relation between the two glands is depicted in Fig. 18.3. The negative feedback by the thyroid hormones is exercised directly on the pituitary as well as through hypothalamus. The action of TRH on pituitary and that of TSH on thyroid cells is mediated by enhanced cAMP synthesis. High concentration of TSH also acts via IP3/DAG–increased intracellular Ca2+ pathway in the thyroid cells.


 

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