SAR of Barbiturates

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Chapter: Medicinal Chemistry : Anticonvulsants

Optimum activity is observed when the substitution at C-5 is phenyl.


SAR of Barbiturates


  1. Optimum activity is observed when the substitution at C-5 is phenyl.

  2. The 5, 5’-diphenyl derivative have less activity than phenobarbitone.

  3. N1and N3substituents in some cases resulted in an increase in activity.


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