1, 4-Dihydro pyridine ring is essential for activity. Substitution at N or oxidation or reduction of the ring reduces or abolishes the activity.
SAR of Dihydropyridines 1, 4-Dihydro pyridine ring is essential for activity. Substitution at N or oxidation or reduction of the ring reduces or abolishes the activity. A phenyl substitution at the 4th position is optimum for the activity. Substitution at para or unsubstituted phenyl ring reduces the activity. The 3rd and 5th position ester group optimizes activity. Placement of electron withdrawing substitution results in agonistic activity. When the ester at C3 and C5 are nonidentical, the C4 become chiral and stereo selectivity is observed. S-enantiomers found to be more effective.
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