SAR of Hydantoins

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Chapter: Medicinal Chemistry : Anticonvulsants

5-phenyl or other aromatic substitution is essential for activity.


SAR of Hydantoins


  • 5-phenyl or other aromatic substitution is essential for activity.

  • Alkyl substituent at position 5 may contribute to sedation, a property absent in phenytoin.

  • Among other hypnotics 1,3-disubstituted hydantoins, exhibit activity against chemically induced convulsion, while it remains ineffective against electric shock induced convulsion.

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