SAR of Phenacemide

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Chapter: Medicinal Chemistry : Anticonvulsants

Various substituents that are tested on the phenyl acetyl urea and their SAR is discussed as given:


SAR of Phenacemide


Various substituents that are tested on the phenyl acetyl urea and their SAR is discussed as given:

  1. Among aliphatic acetyl ureas the highest anticonvulsant activity is found in those derived from the branched chain acids of about 7-carbon atoms.

  2. With a further increase in molecular weight the anticonvulsant activity gradually terminates and hypnotic effect predominates.

  3. Phenacemide is a most active agent among the aromatic acetyl urea.

  4. Any substitution in nitrogen of phenacemide does not increase further the anticonvulsant activity.

  5. The activity decreases with aromatic substituents of phenacemide with a gradual increase in hypnotic activity.

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