Selective Norepinephrine Reuptake Inhibitors (SNERIs)

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Chapter: Medicinal Chemistry : Antidepressants

Antidepressants - Venlafaxine - Selective Norepinephrine Reuptake Inhibitors (SNERIs) - SYNTHESIS AND DRUG PROFILE - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose


SYNTHESIS AND DRUG PROFILE


Selective Norepinephrine Reuptake Inhibitors (SNERIs)

a. Venlafaxine


Synthesis


Properties and uses: It is a white or almost white powder and exhibits the property of polymorphism. Freely soluble in water and in methanol, soluble in anhydrous ethanol, slightly soluble, or practically insoluble in acetone. It is a phenylethylamine bicyclic compound with antidepressant effect similar to TCAs, but with fewer side effects. It is a selective inhibitor of 5-HT and NE reuptake. It also inhibits reuptake of dopamine, but to lesser extent.

Assay: Dissolve the substance in a mixture of 0.01 M hydrochloric acid and ethanol. Perform potentiometric titration with 0.1 M sodium hydroxide.

Storage: It should be stored in well-closed airtight containers.


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