Steroids

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Chapter: Medicinal Chemistry : Steroids

The steroids form a group of structurally related compounds, which are widely distributed in animals and plants.


DRUGS ACTING ON ENDOCRINE SYSTEM

Steroids

INTRODUCTION

The steroids form a group of structurally related compounds, which are widely distributed in animals and plants. The structures of steroids are based on the 1, 2-cyclopentano phenanthrene skeleton.


Steroids consist of four rings. Perhydrophenanthrene (rings A, B, and C) is a completely saturated derivative of phenanthrene, while D is a five-membered cyclopentane ring.

The major therapeutic classes of steroids are the following:

·Anti-inflammatory agents: Cortisone

·Sex hormones: Estrogen, progesterone, and testosterone

·Oral contraceptives: Norethisterone

·Cardiac steroids: Digitoxigenin

·Diuretics: Spironolactone

·Antibiotics: Fusidic acid

·Neuromuscular blockers: Pancuronium chloride

·Vitamin D precursor: Ergosterol

 

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