Tetracyclines

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Chapter: Essential pharmacology : Antimalarial Drugs

These antibiotics have slowly acting and weak erythrocytic schizontocidal action against all plasmodial species. In addition, pre-erythrocytic stage of P. falciparum is inhibited.


TETRACYCLINES

 

These antibiotics have slowly acting and weak erythrocytic schizontocidal action against all plasmodial species. In addition, pre-erythrocytic stage of P. falciparum is inhibited. They are never used alone to treat malaria, but only in combination with quinine or S/P for the treatment of chloroquine resistant falciparum malaria. Tetracycline 250 mg QID or doxycycline 100 mg OD are equally efficacious. Doxycycline 200 mg/ day has also been combined with artesunate to treat mefloquine/chloroquine/S/Presistant falciparum malaria in Thailand.

 

Doxycycline 100 mg/day is used as a 2nd line prophylactic for travellers to chloroquine-resistant P. falciparum areas.

 

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