The Cardiovascular Spectrum of Adverse Drug Reactions

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Chapter: Pharmacovigilance: The Cardiovascular Spectrum of Adverse Drug Reactions

Undesired sequelae of pharmacologic agents encom-pass a wide range of adverse cardiovascular effects, including proarrhythmic, atherogenic, myopathic and valvular consequences.


The Cardiovascular Spectrum of Adverse Drug Reactions

Undesired sequelae of pharmacologic agents encom-pass a wide range of adverse cardiovascular effects, including proarrhythmic, atherogenic, myopathic and valvular consequences (Table 41.1). In this chapter, we will focus on three agents, each demonstrating a different undesired clinical cardiovascular drug effect. The mode of identification and subsequent scientific investigators and regulatory steps are summarized for dofetilide’s proarrhythmic characteristics, cardiac valvular effects of appetite suppressants and oestro-gen’s venous thrombogenicity.



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