The ideal solvent is cheap, nontoxic, and noninflammable.
THE CHOICE OF SOLVENT
The
ideal solvent is cheap, nontoxic, and noninflammable. It is highly selective,
dissolving only the wanted constituents of the solid. It should have a low
vis-cosity, allowing easy movement through a bed of solids, and, if the
resulting solution is to be concentrated by evaporation, a high vapor pressure.
These factors greatly limit the number of solvents of commercial value. Water and
alcohol, and mixtures of the two are widely used. Both, however, are
non-selective leaching varying proportions of gums, mucilages, and other
unwanted components. Most of the tinctures and liquid extracts used in pharmacy
are simple, impure extracts made with water or mixtures of water and alcohol.
Acidified or alkaline mixtures of water and alcohol are used to extract insulin
from minced pancreas. A more selective extraction is given by petroleum
sol-vents and benzene and related solvents. In the preparation of many pure
alkaloids, the powdered material is moistened with an alkaline solution, packed
into a bed, and leached with petroleum. Subsequent purification by fractional
crystallization is facilitated by the absence of gums. Acetone and chlorinated hydrocarbons
also find applications in leaching. In some cases, specific prop-erties of the
wanted constituents may suggest a particular solvent. Eugenol, for example, can
be readily extracted from cloves with a solution of potassium hydroxide.
Related Topics
TH 2019 - 2024 pharmacy180.com; Developed by Therithal info.