Tissue storage

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Chapter: Essential pharmacology : Pharmacokinetics; Membrane Transport, Absorption And Distribution Of Drugs

Drugs sequestrated in various tissues are differentially distributed, tend to have large volume of distribution and long duration of action...


TISSUE STORAGE

 

Drugs may also accumulate in specific organs by active transport or get bound to specific tissue constituents (see box).

 

Drugs sequestrated in various tissues are differentially distributed, tend to have large volume of distribution and long duration of action. Some may exert local toxicity due to high concentration, e.g. tetracyclines on bone and teeth, chloroquine on retina, streptomycin on vestibular apparatus, emetine on heart and skeletal muscle. Drugs may also selectively bind to specific intracellular organelle, e.g. tetracycline to mitochondria, chloroquine to nuclei.

 

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