With the latest therapeutic trend towards aromatherapy and excessive use of essential oils under the labels of natural products, the knowledge of toxicity of essential oils has become important to avoid their abusive use.
TOXOCITY OF ESSENTIAL OILS
With the latest therapeutic trend towards aromatherapy and
excessive use of essential oils under the labels of natural products, the
knowledge of toxicity of essential oils has become important to avoid their
abusive use.
As a general rule, the acute toxicity of essential oils by
the oral route is low or very low; e.g. many of the oils used have an LD50
between 2 and 5g/kg body weight (e.g. anise, eucalyptus and clove) and for most
of them greater than 5 g/kg body weight (e.g. chamomile, citronella, lavender,
marjoram and vetiver). Other oils have further low LD50 between 1
and 2 g/kg for sweet basil, taragon, hyssop (1.5 g/kg), savoury (1.37 g/kg),
sassafras (1.9 g/kg), winter green (0.9–3.25 g/kg), chenopodium (0.25 g/kg),
thuja (0.83 g/kg), pennyroyl (0.4 g/kg) and mustard oil (0.34 g/kg).
A review of the available literature shows that serious
accident involves the young children, due to the ingestion of oils such as
clove (eugenol) eucalyptus, pennyroyl (pulegone), winter green (methyl
salicylate deadly) and parsley (apiole) in large quantity.
The chronic toxicity of essential oils is also not well
known at least for uses, such as aromatherapy as well as for any other route of
administration as the doses in which they are used are too low for chronic
toxicity.
At present in India about 30% of the fine chemicals used
annually in perfumes and flavour are obtained from essential oils. The total
consumption of perfumery and flavouring materials in India is about 4,800
metric tonne/ annum. The food technology, oral hygiene and pharmaceutical
flavour share around 900 metric tonnes and rest represents perfumery.
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