Vinyl pyrimidines
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Vinyl pyrimidines: Pyrantel (Antiminth, Combantrin) - Synthesis and Drug Profile
Anthelmintics - Synthesis and Drug Profile
Vinyl pyrimidines
Pyrantel (Antiminth, Combantrin)
Synthesis
Mode of action: Pyrantel is a depolarizing neuromuscular
blocking agent. It induces marked persistent activation of the nicotinic
receptors, which result in spastic paralysis of the worm. It is an alternative
to mebendazole in the treatment of ascariasis and enterobiasis.
Properties and uses: It is a pale yellow or yellow powder,
practically insoluble in water and in methanol, soluble in dimethyl sulphoxide.
It is also as investigational drug for the treatment of hookworms,
moniliformis, and trichostrongylus infections.
Assay: To the sample add acetic anhydride and glacial acetic acid, heat
and stir. Allow to cool and titrate with 0.1 M perchloric acid. Determine the
end point potentiometrically.
Doses: The dose for oral suspension or liquid is 50 mg/ml. A single
dose of 11 mg/kg for ascarasis and enterobiasis.
