Calcium Channel Blockers

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Chapter: Medicinal Chemistry : Antiarrhythmic Drugs

Antiarrhythmic Drugs : Calcium Channel Blockers : Synthesis and Drug Profile - i. Verapamil (Calaptin, Vasopten) ii. Diltiazem (Dilzem, Angizem, Cardisec)


SYNTHESIS AND DRUG PROFILE

Calcium Channel Blockers

This is discussed in detail under Antianginals.

i. Verapamil (Calaptin, Vasopten)

Dose: Daily oral dose is 180 to 480 mg in acute cases, 5 to 10 mg slow I.V. over 2 min.

ii. Diltiazem (Dilzem, Angizem, Cardisec)

Dose: The usual dose is 60–90 mg of diltiazem, which can be given every 6 h for prophylactic control against paroxysmal supraventricular tachycardia.


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