Transdermal Androgen

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Chapter: Essential pharmacology : Androgens and Drugs for Erectile Dysfunction

Recently delivery of androgen across skin has been achieved by developing suitable solvents and absorption facilitators. By cutaneous delivery, testosterone/dihydrotestosterone circumvent hepatic first pass metabolism; uniform blood levels are produced round the clock.


TRANSDERMAL ANDROGEN

 

Recently delivery of androgen across skin has been achieved by developing suitable solvents and absorption facilitators. By cutaneous delivery, testosterone/dihydrotestosterone circumvent hepatic first pass metabolism; uniform blood levels are produced round the clock. A gel formulation has been marketed for once daily application in hypogonadism and impotence.

 

ANDRACTIM: Dihydrotestosterone 25 mg/g gel (100 g tube); 5–10 g gel to be applied over nonscrotal skin once daily.

 

Fixed dose combinations of testosterone with yohimbine, strychnine and vitamins are banned in India.

 

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