Anticholinergic Drugs : Amino Amides - Synthesis and Drug Profile - Tropicamide (Tropicamet, Tmide Ed, Optimide) - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
Amino Amides Properties and uses: It is a white or almost white crystalline powder, soluble in alcohol and methylene chloride, but slightly soluble in water. Used to induce mydriasis and cycloplegia in ophthamologic practice and it has short duration of action. Assay: Dissolve the sample in anhydrous acetic acid, to this add naphtholbenzein solution, and titrate with 0.1 M perchloric acid. End point is the change of colour from orange to green. Synthesis Route I. From. Tropic acid Route II. From: Tropic acid Storage: It should be stored in well-closed airtight containers and protected from light. Dose: The usual adult topical dose is 1 to 2 drops of a 0.5% or 1% solution to the conjunctiva; for mydriasis 0.5% solution is employed, and for cycloplegia 1% solution. Dosage forms: Tropicamide eye drops I.P., B.P.SYNTHESIS AND DRUG PROFILE
i. Tropicamide (Tropicamet, Tmide Ed, Optimide)
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