As already stated, chronic, recurrent and device-related infections are now recognized to be associated with biofilm formation. Biofilms, as discussed above, possess multiple mechanisms that render them less susceptible to antibiotic treatment than the same isolate in the planktonic mode of growth.
TREATMENT OF CHRONIC BIOFILM INFECTIONS
As already stated,
chronic, recurrent and device-related infections are now recognized to be
associated with biofilm formation. Biofilms, as discussed above, possess multiple
mechanisms that render them less susceptible to antibiotic treatment than the
same isolate in the planktonic mode of growth. The antibiotics we have today
were all selected for efficacy against planktonic cultures and all our
diagnostics are based on planktonic assays. Finally, we now recognize that MIC
values provide us with little relevant information on how to treat biofilm
infections. Clearly, a new paradigm for treatment of biofilms is needed.
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